Publications by authors named "B E Groen"
Background: People with incomplete spinal cord injury (iSCI) often have gait impairments that negatively affect daily life gait performance (i.e., ambulation in the home and community setting) and quality of life.
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- Amino acids, especially histidine, can influence metabolism and glycemic control, primarily investigated through a clinical study involving participants with type 2 diabetes and healthy controls.
- After two weeks of oral histidine supplementation, researchers saw improved glycemic markers and an increase in MAIT cells, suggesting a link between histidine metabolism, gut bacteria, and immune response.
- The study proposes that dietary histidine may affect MAIT cells through changes in gut microbiota and specific gene expression, highlighting potential pathways for future research in managing glycemic control.
Visual information is essential to navigate the environment and maintain postural stability during gait. Visual field rotations alter the perceived heading direction, resulting in gait trajectory deviations, known as visual coupling. It is unclear how center of mass (CoM) control relative to a continuously changing base of support (BoS) is adapted to facilitate visual coupling.
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- The study evaluated the reliability and validity of the Walking Adaptability Ladder test for Kids (WAL-K) in assessing walking adaptability in 6-12 year old children with Cerebral Palsy (CP).
- It involved 36 children with varying levels of CP and analyzed their WAL-K scores alongside typically developing (TD) children, showing that CP children had significantly worse scores than TD peers.
- Results indicated high reliability (ICCs between 0.997 and 1.000) and positive correlations with the 10 times 5 m Sprint Test, suggesting that WAL-K is a promising tool for assessing walking adaptability in this population, though future research is needed to evaluate its responsiveness to change.
Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling.
CPT Pharmacometrics Syst Pharmacol
April 2024
Optimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric physiologically-based pharmacokinetic (PBPK) models may incorporate RT activity, but this requires ontogeny profiles for RT activity in children, especially neonates, to predict drug disposition. Therefore, RT expression measurements from human kidney postmortem cortical tissue samples were normalized to represent a fraction of mature RT activity.
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