Publications by authors named "B E Giles"
Background: Over the past decade, progress in the diagnosis and treatment of Non-Small Cell Lung Cancer (NSCLC) has led to the identification of many targeted mutations. This has enhanced PFS and OS in both advanced and early-stage NSCLC. The current standard of care for stage III NSCLC varies, and it may combine chemotherapy with either immunotherapy or radiotherapy.
View Article and Find Full Text PDFDespite being designed for smoking cessation, e-cigarettes and their variety of flavors have become increasingly attractive to teens and young adults. This trend has fueled concerns regarding the potential role of e-cigarettes in advancing chronic diseases, notably those affecting the cardiovascular system. E-cigarettes contain a mixture of metals and chemical compounds, some of which have been implicated in cardiovascular diseases like atherosclerosis.
View Article and Find Full Text PDFBackground: Organophosphate esters (OPEs) are flame retardants and plasticizers used in consumer products. OPEs are found ubiquitously throughout the environment with high concentrations in indoor house dust. Exposure to individual OPEs is associated with immune dysfunction, particularly in macrophages.
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- Asthma shows significant differences in prevalence and characteristics among various ancestral groups, yet the reasons for these disparities are not well understood.
- The Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) is analyzing genetic information from individuals of African ancestry to identify specific genes related to asthma.
- In their findings, they discovered 389 differentially expressed genes (DEGs), with key networks linked to immune response and wound healing, revealing three main areas of dysregulation important for understanding asthma within these populations.
Pediatric pulmonology fellowship training programs are required by the Accreditation Council for Graduate Medical Education to report Pediatric Subspecialty Milestones biannually to track fellow progress. However, several issues, such as lack of subspecialty-specific context and ambiguous language, have raised concerns about their validity and applicability to use for fellow assessment and curriculum development. In this Perspective, we briefly share the process of the Pediatric Pulmonology Milestones 2.
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