Publications by authors named "B E Garcia-Figueroa"
Article Synopsis
- Anti-αGal IgE antibodies are responsible for αGal-syndrome (AGS), an allergic condition that develops in individuals after hard tick bites, leading to increased sensitivity to αGal.
- The study explores the creation of polymeric αGal-glycoconjugates aimed at inhibiting these IgE antibodies, with promising results in both human serum samples and a mouse model.
- The findings indicate that a minimum of 27 αGal residues is required for effective inhibition, and the specific polymeric conjugate DP1000-RA0118 demonstrated significant reduction of anti-αGal IgE antibodies, supporting its potential for clinical application in treating AGS.
Unraveling the Diagnosis of Kiwifruit Allergy: Usefulness of Current Diagnostic Tests.
J Investig Allergol Clin Immunol
June 2022
Objectives: To determine the usefulness of the in vitro and in vivo methods used in the diagnosis of kiwifruit allergy and to specifically assess the impact of seed proteins on sensitivity.
Methods: We performed skin prick tests (SPTs) using various commercial extracts, homemade pulp, and seed extracts and prick-prick tests with kiwifruit on 36 allergic patients. The presence of specific IgE (sIgE) was assessed using the ImmunoCAP (kiwifruit extract), ELISA (Act d 1, Act d 2), ISAC, and FABER assays.
The introduction of new diagnostic and therapeutic procedures involving allergen exposure may increase the risk of allergic reactions. We designed and distributed an anonymous questionnaire among the allergy units of the Valencian Community in order to collect information on measures to ensure clinical safety. Twelve hospital outpatient clinics and 8 ambulatory care centres reported similar patterns of activities, including the use of critical care units, emergency rooms or day hospitals for higher risk techniques.
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