Publications by authors named "B Durisova"
Higher risk of depression and schizophrenia in descendants of mothers experienced acute infection during the pregnancy has been reported. Since monoamines are fundamental in mentioned psychopathologies, it is possible that maternal immune activation leads to impaired functioning of serotonin (5-HT), noradrenaline, and dopamine neurons in offspring. To test this hypothesis, we examined the effect of maternal immune activation by lipopolysaccharide (LPS) in rats on the excitability of monoamine-secreting neurons in the offspring.
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- SMe1EC2M3 is a pyridoindole derivative similar to the neuroleptic drug carbidine and is hypothesized to have antidepressant-like effects due to its potential as a triple reuptake inhibitor for serotonin, norepinephrine, and dopamine.
- In silico tools (PreADMET and Dragon software) predicted favorable pharmacokinetic properties for SMe1EC2M3, while behavioral tests showed that it reduced immobility and increased swimming time in the forced swim test, indicating antidepressant-like effects.
- Electrophysiological studies revealed that SMe1EC2M3 dose-dependently inhibited neuron excitability in key brain regions associated with mood regulation, and
Background: The antidepressant effect of physical exercise has been reported in several clinical and animal studies. Since serotonin, norepinephrine, and dopamine play a central role in depression, it is possible that the beneficial effects of physical exercise are mediated via monoamine pathways. This study investigates the effects of voluntary wheel running on the excitability of monoamine neurons.
View Article and Find Full Text PDF[Functional liver disorder in relation to decreased titratable acidity of milk].
Vet Med (Praha)
November 1992
The internal environment of 17 dairy cows was observed by help of 23 variables of metabolic profile in blood and milk at lowered titratable acidity of milk (Tab. I) Average values of the observed variables were compared with reference values in a histogramme (Fig. 1).
View Article and Find Full Text PDFThe internal environment of high-yielding dairy cows was investigated in relation to 36 variables of the blood metabolic profile, blood serum, milk and urine, with the incidence of reduced titration acidity milk syndrome. The levels of variables were confronted with references values. At the same time the statistical significance of differences of arithmetical means from the reference mean was calculated.
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