Publications by authors named "B Dreyer"
Caring for Patients Seeking Asylum: Early Data From the Safety Net System in New York City.
J Public Health Manag Pract
December 2024
Context: Over 200 000 people seeking asylum have arrived in New York City from 2022 to 2024.
Program: As the safety net hospital system for our city, New York City (NYC) Health + Hospitals (H + H) has taken the lead in caring for newly arrived asylum seekers. We used electronic medical record data to gain early insights into utilization and needs among these patients.
GALNT2, also known as polypeptide N-acetylgalactosaminyltransferase 2, is an enzyme that catalyzes the initial step of O-linked glycosylation, a crucial posttranslational modification that affects protein folding, stability, and function. Alterations in GALNT2 activity have been implicated in various diseases, such as cancer, metabolic disorders, and cardiovascular diseases, highlighting its importance in maintaining normal physiological functions. To investigate the impact of GalNT2 overexpression in vivo for the first time, we generated a conditional transgenic mouse line in which GalNT2 was expressed specifically in the pancreas.
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- Life evolved in a reducing environment but faced challenges from reactive oxygen species (ROS) during the great oxidation event (GOE), leading to the development of copper-zinc superoxide dismutases (CuZnSODs) in some plants.
- The chemical inhibitor lung cancer screen 1 (LCS-1) was used to study the effects of CuZnSOD inhibition on plant growth, transcription, and metabolism across different species, including bryophytes and vascular plants.
- The results showed that LCS-1 caused oxidative stress and a core physiological response related to glutathione balance in all species, but varying metabolic responses were observed based on the number and types of CuZnSOD isoforms present in each plant.