The Impact of Language Discordance on Acquiring Broad Social History: A Qualitative Study of Patients, Clinicians, and Interpreters.

Background: By acquiring a broad social history (BSH), which includes aspects of patients' social needs in addition to their hobbies and activities, values, and perspectives on care, clinicians can provide more patient-centered care, which is known to improve health outcomes. However, the impact of patient-clinician language discordance on acquisition of BSH has not been well studied.

Objective: To ascertain whether language discordance impacts clinicians' acquisition of patients' BSH by interviewing patients, clinicians, and medical interpreters.

Left atrial appendage anatomy: clinical implications for cardiac procedures.

The Left Atrial Appendage (LAA) is the most common source of thrombi during atrial fibrillation (AF) leading to stroke. With the increasing prevalence of AF and the growing number of patients requiring LAA involved interventions like exclusion and ablation, understanding LAA's anatomical intricacies becomes paramount importance. This study aims to provide anatomical data regarding LAA in relation to these procedures.

Coagulation factor VIII: biological basis of emerging hemophilia A therapies.

Coagulation factor VIII (FVIII) is essential for hemostasis. After activation, it combines with activated FIX (FIXa) on anionic membranes to form the intrinsic Xase enzyme complex, responsible for activating FX in the rate-limiting step of sustained coagulation. Hemophilia A (HA) and hemophilia B are due to inherited deficiencies in the activity of FVIII and FIX, respectively.