Publications by authors named "B Dobner"
Ionizable lipids are a class of pharmaceutical excipients with a main application in lipid nanoparticles for nucleic acid delivery. New ionizable lipids are needed to tune characteristics of lipid-based nucleic acid delivery systems, e.g.
View Article and Find Full Text PDFArticle Synopsis
- The stratum corneum is a crucial barrier in the skin, primarily composed of lipids, particularly ceramides (CERs), which protect against damage.
- Research focused on the α-OH phytosphingosine CER class to examine the differences between the naturally occurring d-form and the synthetically produced l-form in terms of their structural and chemical properties.
- The study found that the d-form creates a beneficial hydrogen bonding network, forming a stable supramolecular lattice, while the l-form lacks this ability, affecting how these CERs behave in both 2D and 3D model systems.
O-1-Alkylglycerols are ubiquitous constituents in various biological materials but their biological significance is still largely unknown. So far, reports about the striking role of structural features on the interfacial properties of 1-O-alkylglycerol monolayers are quite rare. Therefore, in the present paper 1-O-alkylglycerol monolayers are comprehensively characterized on mesoscopic and molecular scales in the accessible ranges of temperature and surface pressure.
View Article and Find Full Text PDFThe physicochemical properties and transfection efficacies of two samples of a cationic lipid have been investigated and compared in 2D (monolayers at the air/liquid interface) and 3D (aqueous bulk dispersions) model systems using different techniques. The samples differ only in their chain composition due to the purity of the oleylamine (chain precursor). Lipid 8 (using the oleylamine of technical grade for cost-efficient synthesis) shows lateral phase separation in the Langmuir layers.
View Article and Find Full Text PDFIn continuation of previous work, we present a new promising DNA carrier, OO4, a highly effective peptide-mimicking lysine-based cationic lipid. The structural characteristics of the polynucleotide carrier system OO4 mixed with the commonly used co-lipid DOPE and the saturated phospholipid DPPE have been studied in two-dimensional and three-dimensional model systems to understand their influence on the physical-chemical properties. The phase behavior of pure OO4 and its mixtures with DOPE and DPPE was studied at the air-water interface using a Langmuir film balance combined with infrared reflection-absorption spectroscopy.
View Article and Find Full Text PDF