Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure: The GALACTIC Randomized Clinical Trial.

Importance: Short-term infusions of single vasodilators, usually given in a fixed dose, have not improved outcomes in patients with acute heart failure (AHF).

Objective: To evaluate the effect of a strategy that emphasized early intensive and sustained vasodilation using individualized up-titrated doses of established vasodilators in patients with AHF.

Design, Setting, And Participants: Randomized, open-label blinded-end-point trial enrolling 788 patients hospitalized for AHF with dyspnea, increased plasma concentrations of natriuretic peptides, systolic blood pressure of at least 100 mm Hg, and plan for treatment in a general ward in 10 tertiary and secondary hospitals in Switzerland, Bulgaria, Germany, Brazil, and Spain.

Antiherpes effect of Melissa officinalis L. extracts.

Studies were carried out on the virucidal and antiviral effects of Melissa officinalis L. extracts (M1, M3, M3 and M4) with respect to Herpes simplex virus type 1 (HSV-1). Virucidal effect was registered within 3 and 6 hours of treatment using M4 administered in MTC.

[Alkaloid Content of Thalictrum minus from the Slavjanka Mountains.].

In Thalictrum minus plants, collected in the Slavjanka Mountains, the alkaloids thalmelatine, thalipine, ocoteine, berberine, thalicarpine and glaucine were quantitatively determined by HPLC.

[Naniprus treatment of hypertensive crises in patients with kidney diseases].

After a brief literature survey, the authors share their experience of the treatment of hypertonic crises and acute left cardiac insufficiency of renal patients via Naniprus, a preparation produced in P.R. of Bulgaria.