Publications by authors named "B Di Benedetto"
Article Synopsis
- Astrocytes are special brain cells that help shape how other brain cells connect and work together, which is super important for a healthy brain.
- When astrocytes don’t work right, it can lead to serious brain problems, especially during the early stages of brain development.
- Scientists are studying how these brain cells develop and how problems with them might cause mental disorders. They’re also looking into how differences between boys and girls could affect these processes.
Clinical and pre-clinical studies of neuropsychiatric (NP) disorders show altered astrocyte properties and synaptic networks. These are refined during early postnatal developmental (PND) stages. Thus, investigating early brain maturational trajectories is essential to understand NP disorders.
View Article and Find Full Text PDFBackground: Identifying sex-related differences/variables associated with 30 day/1 year mortality in patients with chronic limb-threatening ischemia (CLTI).
Methods: Multicenter/retrospective/observational study. A database was sent to all the Italian vascular surgeries to collect all the patients operated on for CLTI in 2019.
Astroglial cells actively partner with several cell types to regulate the arrangement of neuronal circuits both in the developing and adult brain. Morphological features of astroglial cells strongly impact their functional interactions, thereby supporting the hypothesis that aberrancies in glial morphology may trigger the onset of neuropsychiatric disorders. Thus, understanding the factors which modulate astroglial shapes and the development of tools to examine them may help to gain valuable insights about the role of astroglia in physiological and pathological brain states.
View Article and Find Full Text PDFArticle Synopsis
- Neuroinflammation is being recognized as a significant factor in psychiatric disorders, with proteins like C1q and TSPO gaining attention for their roles in this area.
- C1q is involved in synaptic pruning and may contribute to neurodegenerative diseases, while TSPO is linked to various biological functions, and both proteins are elevated in conditions like major depression.
- New research indicates that compounds that enhance GABA receptor activity, such as neurosteroids and TSPO ligands, could have potential therapeutic effects on depression and anxiety, suggesting new treatment pathways.