Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity.

Recombinant human IGF-1 is used to treat severe primary IGF-1 deficiency, but this treatment requires twice-daily injection, often does not fully correct the growth deficit, and has important off-target effects. We therefore sought to target IGF-1 to growth plate cartilage by generating fusion proteins combining IGF-1 with single-chain human antibody fragments that target matrilin-3, a cartilage matrix protein. We previously showed that this cartilage-targeting IGF-1 fusion protein (CV1574-1) promoted growth plate function in a GH-deficient (lit) mouse model.

Photoinduced energy and electron transfer processes in a supramolecular system combining a tetrapyrenylporphyrin derivative and arene-ruthenium metalla-prisms.

A supramolecular system, consisting of a tetrapyrenylporphyrinic core surrounded by arene-ruthenium prisms, has been assembled and characterized by means of electrochemical and photophysical techniques. The photophysical study shows that quantitative energy transfer from the peripheral pyrenyl units towards the central porphyrin core is operative in the tetrapyrenylporphyrinic system. Interestingly, encapsulation of the pyrenyl units into the ruthenium cages affects the photophysics of the central porphyrin component, since its emission quantum yield is reduced in the supramolecular array.

Rationalization of the structural, electronic and photophysical properties of silver(I) halide -picolylamine hybrid coordination polymers.

Hybrid coordination polimers based on AgX (with X = Cl, Br) and 2-, 3-, 4-picolylamine ligands, obtained by means of solvent-free methods, show peculiar luminescence properties that are strongly influenced by their structural motif, which in turn is defined by the adopted isomer of the ligand. A comprehensive study, combining photophysical methods and DFT calculations, allowed to rationalize the emissive behaviour of such hybrid coordination polymers in relation to their crystal structures and electronic properties. By means of luminescence measurements at variable temperatures, the nature of the emissive excited states and their deactivation dynamics was interpreted, revealing XMLCT transitions in the [(AgX)(2-pica)] compounds, a TADF behaviour in the case of 3-pica derivatives, and a dual emission at room temperature for the [(AgX)(4-pica)] family.

High-Statistics Measurement of Collins and Sivers Asymmetries for Transversely Polarized Deuterons.

New results are presented on a high-statistics measurement of Collins and Sivers asymmetries of charged hadrons produced in deep inelastic scattering of muons on a transversely polarized ^{6}LiD target. The data were taken in 2022 with the COMPASS spectrometer using the 160 GeV muon beam at CERN, statistically balancing the existing data on transversely polarized proton targets. The first results from about two-thirds of the new data have total uncertainties smaller by up to a factor of three compared to the previous deuteron measurements.