Publications by authors named "B Del Carmelo Gracia Tello"

Introduction: The importance of nurturing care for child development is well-established, and parents play a central role in providing this care. However, cultural values and traditions can influence child-rearing practices, and there are gaps in child welfare in Ecuador. Two research questions delve into caregivers' definitions of nurturing care for children aged 0-5 and its alignment with World Health Organization's concept.

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Modified vaccinia Ankara (MVA) virus is a widely used vaccine platform, making accurate titration essential for vaccination studies. However, the current plaque forming unit (PFU) assay, the standard for MVA titration, is prone to observer bias and other limitations that affect accuracy and precision. To address these challenges, we developed a new flow cytometry-based quantification method using a highly specific monoclonal antibody (mAb) for the detection of MVA-infected cells, as a more accurate titration assay.

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Article Synopsis
  • Epstein-Barr virus (EBV) is linked to various cancers and diseases, yet despite extensive research, an effective vaccine has not been licensed, largely due to past efforts focusing on a single protein.
  • The study presents a new vaccine, MVA-EBV5-2, targeting five EBV entry glycoproteins, demonstrating genetic stability and the ability to produce strong immune responses in animal models.
  • Results showed that this vaccine generated higher levels of neutralizing antibodies in mice and rhesus macaques compared to traditional methods, effectively reducing EBV infection in treated models.
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Objectives: To identify differences in the mean vitamin D concentrations in samples obtained from a private laboratory in Quito and to explore their relationship with the pre-pandemic and pandemic periods spanning from 2018 to 2022.

Design: A combination of an interrupted time series design and a retrospective cross-sectional approach.

Setting And Participants: The study involved 9285 participants who had their 25-hydroxyvitamin D (25(OH)D) levels tested at a well-known private laboratory in Quito, Ecuador, from 2018 to 2022.

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Background: During the 1990s, global eating habits changed, affecting poorer and middle-income nations, as well as richer countries. This shift, known as the "obesity transition," led to more people becoming overweight or obese worldwide. In Ecuador, this change is happening, and now, one in three children is affected by overweight or obesity (OW/OB).

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