Publications by authors named "B Deepaisarnsakul"
Article Synopsis
- - The study examined nitrite and iNOS levels in patients with primary knee osteoarthritis (OA) and compared them to healthy controls, revealing elevated levels in the OA group.
- - Out of 30 OA patients and 30 healthy controls, significant increases in plasma and synovial fluid nitrite and iNOS levels were observed in the OA group (p < 0.05).
- - Immunohistochemical analysis showed nitrotyrosine present in various cells of the synovial tissue in OA patients, suggesting a potential link between these reactive nitrogen species and joint damage in knee OA.
Background: Osteoarthritis (OA) is a chronic progressive degenerative joint disorder which is characterised by strongly age-related regressive changes in articular cartilage. The objective of this study was to evaluate oxidative stress and antioxidant parameters in plasma and synovial fluid of patients with primary knee osteoarthritis.
Material And Methods: Thirty-five OA patients and 35 healthy controls were recruited for this study.
Osteoarthritis (OA) is a degenerative joint disorder resulting in destruction of articular cartilage, osteophyte formation, and subchondral bone sclerosis. In recent years, numerous genetic factors have been identified and implicated in causing osteoarthritis. One such genetic defect is a single nucleotide polymorphism at position -1612 of matrix metalloproteinase-3 (MMP-3) promoter region, known to lead to three possible genotypes, 5A/5A, 6A/6A, and 5A/6A.
View Article and Find Full Text PDFOsteoarthritis is a chronic progressive degenerative joint disease characterized by age-related regressive change in articular cartilage. A single nucleotide polymorphism has been described at position -174 of the interleukin-6 (IL-6) promoter region, leading to three possible genotypes, GG, GC, and CC. We investigated a possible association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population.
View Article and Find Full Text PDFKnee osteoarthritis is a common cause of severe pain and functional limitation. Total knee arthroplasty is an effective procedure to relieve pain, restore knee function, and improve quality of life for patients with end stage knee arthritis. The aim of this study was to investigate the inflammatory process in patients with primary knee osteoarthritis before surgery and in subsequent periods following total knee arthroplasty.
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