Ferritin-based disruptor nanoparticles: A novel strategy to enhance LDL cholesterol clearance via multivalent inhibition of PCSK9-LDL receptor interaction.

Hypercholesterolemia, characterized by elevated low-density lipoprotein (LDL) cholesterol levels, is a significant risk factor for cardiovascular disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in cholesterol metabolism by regulating LDL receptor degradation, making it a therapeutic target for mitigating hypercholesterolemia-associated risks. In this context, we aimed to engineer human H ferritin as a scaffold to present 24 copies of a PCSK9-targeting domain.

Gold Nanorods as Radiopharmaceutical Carriers: Preparation and Preliminary Radiobiological In Vitro Tests.

Low-energy electrons (Auger electrons) can be produced via the interaction of photons with gold atoms in gold nanorods (AuNRs). These electrons are similar to those emitted during the decay of technetium-99m (Tc), a radioactive nuclide widely used for diagnostics in nuclear medicine. Auger and internal conversion (IC) electron emitters appropriately targeted to the DNA of tumors cells may, therefore, represent a new radiotherapeutic approach.

Nanoparticle Impact on the Bacterial Adaptation: Focus on Nano-Titania.

Titanium dioxide nanoparticles (nano-titania/TiO NPs) are used in different fields and applications. However, the release of TiO NPs into the environment has raised concerns about their biosafety and biosecurity. In light of the evidence that TiO NPs could be used to counteract antibiotic resistance, they have been investigated for their antibacterial activity.

Exposure to TiO Nanoparticles Increases Infection of Intestinal Epithelial Cells.

Titanium dioxide nanoparticles (TiO NPs) are widely used in a variety of consumer products. Cellular exposure to TiO NPs results in complex effects on cell physiology that could impact biological systems. We investigated the behavior of in intestinal epithelial cells pre-treated with either a low or high (1 and 20 µg/cm) dose of TiO NPs.