Small Airway Disease in Pre-Chronic Obstructive Pulmonary Disease with Emphysema: A Cross-Sectional Study.

Small airway disease is an important pathophysiological feature of chronic obstructive pulmonary disease (COPD). Recently, "pre-COPD" has been put forward as a potential precursor stage of COPD that is defined by abnormal spirometry findings or significant emphysema on computed tomography (CT) in the absence of airflow obstruction. To determine the degree and nature of (small) airway disease in pre-COPD using microCT in a cohort of explant lobes/lungs.

Silicosis as an unusual cause of symptomatic cervical adenopathy.

A case of symptomatic cervical adenopathy is reported as a presentation of silicosis. Silicosis is one of the most important occupational health diseases worldwide caused by the inhalation of airborne silica particles. The presence of thoracic adenopathies is a common clinical feature of silicosis, cervical silicotic adenopathies on the other hand are rare and unknown to most clinicians and can therefore lead to a differential diagnostic problem.

Practical approach to patients presenting with multiple synchronous suspect lung lesions: a reflection on the current TNM classification based on 54 cases with complete follow-up.

Objectives: To examine the survival after surgical treatment of patients presenting with two synchronous suspect lung lesions, and to reflect on the recent TNM classification, which has upgraded patients with two malignant lung lesions of the same histology into the T4 (both lesions in the same ipsilateral lobe) or M1 (different lobes or lungs) category.

Methods: Retrieval of all consecutive patients with a diagnosis of two synchronous suspect lung lesions in the prospective database of the Leuven Lung Cancer Group in the interval between 1990 and 1994. Analysis of characteristics and survival of all patients, who underwent surgical resection with intention to cure for both lesions.