Overcoming drug resistance through extracellular vesicle-based drug delivery system in cancer treatment.

Drug resistance is a major challenge in cancer therapy that often leads to treatment failure and disease relapse. Despite advancements in chemotherapeutic agents and targeted therapies, cancers often develop drug resistance, making these treatments ineffective. Extracellular vesicles (EVs) have gained attention for their potential applications in drug delivery because of their natural origin, biocompatibility, and ability to cross biological barriers.

Feasibility of occlusal plane in predicting the changes in anteroposterior mandibular position: a comprehensive analysis using deep learning-based three-dimensional models.

Background: A comprehensive analysis of the occlusal plane (OP) inclination in predicting anteroposterior mandibular position (APMP) changes is still lacking. This study aimed to analyse the relationships between inclinations of different OPs and APMP metrics and explore the feasibility of OP inclination in predicting changes in APMP.

Methods: Overall, 115 three-dimensional (3D) models were reconstructed using deep learning-based cone-beam computed tomography (CBCT) segmentation, and their accuracy in supporting cusps was compared with that of intraoral scanning models.

ABO Blood Group and Risk Associated With Sepsis-Associated Thrombocytopenia: A Single-Center Retrospective Study.

Objectives: This study aimed to investigate the relationship between ABO blood group and sepsis-associated thrombocytopenia (SAT).

Design And Setting: The primary outcome was SAT within the first 72 hours of ICU admission.

Patients: The retrospective study included 9113 patients diagnosed with sepsis from January 2014 to December 2022.

Scleral Contact Lens Benefits for Myopic Patients With Regular Corneas: A Prospective Randomized Study.

Objectives: To evaluate the impact of scleral contact lens (SL) wear on the visual quality and the ocular surface wettability in myopic patients with regular corneas.

Methods: This prospective, randomized, controlled study enrolled a total of 80 myopes with regular corneas. Subjects were randomly allocated to wear SL or rigid corneal lens (RCL) for 3 months.

Nerelimomab Alleviates Capsaicin-Induced Acute Lung Injury by Inhibiting TNF Signaling and Apoptosis.

Capsaicin is commonly used as a flavoring and a riot control agent. However, long-term exposure or high doses can cause acute lung injury in military and police personnel. The mechanisms underlying capsaicin-induced pulmonary toxicity remain unclear.