Indian Trial of Tranexamic acid in Spontaneous Intracerebral Hemorrhage study protocol.

Rationale: Early mortality in intracerebral hemorrhage (ICH) is due to hematoma volume (HV) expansion, and there are no effective treatments available other than reduction in blood pressure. Tranexamic acid (TXA) a hemostatic drug that is widely available and safe can be a cost-effective treatment for ICH, if proven efficacious.

Hypothesis: Administration of TXA in ICH patients when given within 4.

Ethanol-assisted stimulated graphene oxide as support for CuO/NiO nanoparticles.

Herein we report the first successful synthesis of ethanol-assisted generated reduced graphene oxide as a support for CuO/NiO nanoparticles. Through the strategic incorporation of Cu and Ni precursors into ethanol, followed by thermal treatment, we achieved the fabrication of reduced graphene oxide-supported CuO/NiO nanoparticles. The material underwent thorough characterization using FT-IR, XRD, TEM, XPS, Raman, and UV-DRS analysis.

In Situ Stabilization of Bi Nanoparticles into the Nanopores of Modified Montmorillonite: Efficient Heterogeneous Catalysts for Reduction of 4-Nitrophenol.

Here, we report the in situ generation of Bi nanoparticles (BiNPs) into a nanoporous matrix by impregnation of bismuth chloride and subsequent reduction with sodium borohydride. The nanoporous matrix was created by acid activation of natural montmorillonite clay under controlled conditions with the aim that it may serve as a host for BiNPs. The characterization of stabilized BiNPs was done by using Fourier-transform infrared (FTIR), powder X-ray diffraction (PXRD), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), transmission electron microscopy (TEM), and field emission scanning electron microscopy-energy dispersive X-ray (FESEM-EDX) techniques.

Genomic analysis of acid tolerance genes and deciphering the function of gene in mitigating acid tolerance in .

Adverse environmental conditions, such as acid stress, induce bacteria to employ several strategies to overcome these stressors. These strategies include forming biofilms and activating specific molecular pathways, such as the general stress response (GSR). The genome of strain G18 was sequenced using the Illumina NextSeq 500 system, resulting in a assembly of 80 scaffolds.

Ruthenium(II)-Catalyzed Oxidative Annulation of Imidazo[1,5-a]quinolin-2-iums Salts and Internal Alkynes via C-H Bond Activation.

Ruthenium(II)-catalyzed synthesis of π-conjugated fused imidazo[1,5-a]quinolin-2-ium derivatives have been achieved via C-H activation of quinoline-functionalized NHC (NHC=N-heterocyclic carbene) and oxidative coupling with internal alkynes. The reaction occurred with high efficiency, broad substrate scope, tolerates a wide range of functional groups and utilized into a gram-scale. Synthetic applications of the coupled product have been exemplified in the late-stage derivatization of various highly functionalized scaffolds.