Publications by authors named "B D Rubin"
Background: Allergic rhinitis (AR) and acute non-allergic rhinosinusitis (ARS) often present with similar symptoms. While these are generally differentiated by history and occasionally by secretion cell counts, there are few data temporally comparing these conditions.
Methods: A prospective, observational study was conducted to assess nasal mucus properties, nasal obstruction, nasal secretion cells, and health related QOL during the acute phase (Day 5) and during a later phase of illness (Day 14/28).
Article Synopsis
- - The study focused on 44 cases of epithelioid myxofibrosarcoma (eMFS), a rare and aggressive cancer variant, examining factors like morphologic structure and cancer grading, revealing that the majority displayed diffuse epithelioid characteristics and high FNCLCC grades.
- - Among the patients, mostly older adults with a higher incidence in males, local recurrence and metastasis were common; specifically, 10 out of 22 monitored patients developed metastases, typically to regional lymph nodes, regardless of tumor grade.
- - An interesting note is that some cases initially diagnosed as eMFS shared genetic mutations typically seen in other UV-driven cancers, suggesting possible misdiagnosis and the need for careful evaluation
Purpose: To determine the efficacy and safety of repetitive transorbital alternating current stimulation (rtACS) treatment by assessing vision-related quality of life and visual function outcome in subjects treated with rtACS versus sham-control.
Study Design: Double masked, randomized, sham-controlled clinical trial (NCT03188042).
Subjects: Sixteen subjects with moderate-to-advanced glaucoma (visual field [VF] mean deviation [MD] ≤-6.
Article Synopsis
- The study aimed to create a predictive tool to determine which patients with mild traumatic brain injury (mTBI) and subdural hematoma (SDH) may need neurosurgical intervention, as current methods are unreliable and lead to unnecessary treatments.
- Conducted across six trauma centers, the research analyzed 1,333 patients admitted between 2016 and 2020, using variables like hematoma thickness and Glasgow Coma Scale scores to inform predictions.
- Results showed a neurosurgical intervention rate of 8.8%, with key factors identified for predicting surgical need while maintaining a sensitivity of 100%.
Article Synopsis
- CIC-rearranged sarcomas (CRS) are aggressive tumors often driven by a specific fusion gene (CIC::DUX4), which can be difficult to detect through molecular testing due to variability in the fusion breakpoints.* -
- The study evaluated the effectiveness of DUX4 immunohistochemistry (IHC) in identifying CRS by analyzing 48 confirmed CRS cases alongside 105 non-CRS cases across various types of tumors.* -
- DUX4 IHC showed a sensitivity of 98% and specificity of 100% for diagnosing CRS, making it a reliable marker to assist in detecting these tumors, despite one false negative case involving a different fusion.*