Publications by authors named "B D Ratner"
The Origins of Engineered Biomaterials: NSF-Funded, University of Washington Engineered Biomaterials (UWEB).
Bioengineering (Basel)
November 2024
The University of Washington Engineered Biomaterials (UWEB) Engineering Research Center (ERC) was funded from 1996 to 2007 by the U.S. National Science Foundation.
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- Current treatments for intracranial aneurysms are mainly surgical or endovascular, but not all aneurysms can be treated this way.
- Research suggests that targeting specific molecular pathways linked to aneurysm development, particularly through low frequency mutations in cancer-related genes, may lead to better outcomes.
- This review discusses the role of these somatic variants in aneurysm pathogenesis and explores potential gene therapy techniques, including targeted delivery of chemotherapeutics.
Porous precision-templated scaffolds (PTS) with uniform, interconnected, 40 μm pores have shown favorable healing outcomes and a reduced foreign body reaction (FBR). Macrophage receptor with collagenous structure (MARCO) and toll-like receptors (TLRs) have been identified as key surface receptors in the initial inflammatory phase of wound healing. However, the role of MARCO and TLRs in modulating monocyte and macrophage phenotypes within PTS remains uncharacterized.
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