Publications by authors named "B D Pinto"
Introduction: Elevated central aortic pressure, cardiac output and peripheral vascular resistance contribute to high morbidity in relation to end organ dysfunction in obstructive and non-obstructive coronary artery disease (NOCAD) cases despite revascularization. Bisoprolol preempts further progression of left ventricular dysfunction in such cases due to anti-ischemic and anti-hypertensive effects, further extending its evaluation in local Indian settings.
Methods: Post-hoc analyses of NOCAD patients with epicardial stenosis (N=378, 30 to 70% stenosis) from cross-sectional analyses conducted across eighty centers in India.
Article Synopsis
- * This technique is particularly useful for studying the effects of antimitotic drugs, which disrupt cell division by targeting key components like microtubules and kinases, providing insights that traditional methods can't offer.
- * The chapter outlines a detailed protocol for using time-lapse microscopy on A549 lung cancer cells treated with the drug BI2536, including the necessary software for capturing and analyzing the imaging data.
Article Synopsis
- Head and neck cancer (HNC), particularly oral squamous cell carcinoma (OSCC), is increasingly prevalent and often resistant to standard treatments like surgery and chemotherapy.
- The research focuses on combining Cetuximab, an EGFR inhibitor, with other small molecules that target mitotic proteins (MPS-1, Aurora-B, KSP) to improve cancer treatment effectiveness.
- Results indicate that this combination enhances cancer cell death and shows significant clinical relevance, suggesting a new strategy to tackle OSCC more effectively.
The evolutionary classification of protein domains (ECOD) classifies protein domains using a combination of sequence and structural data (http://prodata.swmed.edu/ecod).
View Article and Find Full Text PDF