Publications by authors named "B D Parikh"
The impact of FDA-cleared molecular solutions for BK polyomavirus quantitation.
J Clin Microbiol
January 2025
Accurate detection and monitoring of BK polyomavirus (BKV) infection is of critical importance in the post-transplant period, guiding treatment decisions that balance the anti-rejection effects of immune suppression with host-protective effects of immune defense. Historically, test methods for BKV have been independently developed by laboratories to address this unmet need. However, these assays can suffer from inconsistencies in analytical variability, which in turn have hindered the establishment of commutable and clinically actionable viral load thresholds for clinical management.
View Article and Find Full Text PDFPathogenic variants in the receptor tyrosine kinase TIE2, encoded by TEK, are known to cause vascular malformations (VMs). In this study, we retrospectively reviewed the deidentified data generated through clinical NGS testing in our laboratory and found 88 VM cases with a total of 107 clinically significant TEK variants. Among those, 23 unique variants at the amino acid level were identified, including five novel (p.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the occurrence of extra-musculoskeletal manifestations (EMMs) in patients with psoriatic arthritis (PsA) or axial spondyloarthritis (axSpA) treated with a specific medication, upadacitinib (UPA15).
- Data from five clinical trials were analyzed to compare adverse events like uveitis and inflammatory bowel disease (IBD) among patients receiving either UPA15, a placebo, or adalimumab (ADA).
- Results showed that most patients did not have a history of EMMs, and the occurrence of uveitis and IBD was generally low, particularly in those treated with UPA15 compared to the placebo.
Learning to Control Complex Robots Using High-Dimensional Body-Machine Interfaces.
ACM Trans Hum Robot Interact
September 2024
Article Synopsis
- * In a study involving non-injured participants, the effectiveness of a high-dimensional BoMI to control a robotic arm was examined over five sessions.
- * Findings indicate that how robot control is mapped from human inputs affects learning; while joint space control is easier to start with, task space control leads to better long-term performance and learning outcomes.
Article Synopsis
- Disorders of somatic mosaicism (DoSMs) are rare genetic conditions that occur due to changes in cells after fertilization, and current guidelines for genetic variant interpretation are not well-suited for these disorders.* -
- The Brain Malformations Variant Curation Expert Panel (BMVCEP) has adapted existing guidelines for brain-related DoSMs, but their applicability to other DoSM types is limited.* -
- Researchers at Washington University have made modifications to the BMVCEP framework to enhance variant classification for broader DoSMs, which could lead to more accurate diagnoses and better clinical care.*