Characterization of suppressor T cells in graft-versus-host reactions.

Intravenous (i.v.) immunization of mice with irradiated (2000 rads) allogeneic lymphoid cells induces the generation of suppressor T cells.

Synergism of T lymphocyte subsets in the response to Mls-locus coded antigens during graft-versus-host reaction.

After transplantation of lymphoid cells into lethally irradiated (semi)allogeneic mice specific anti-host directed effector T cells are generated. This can be demonstrated using a delayed type hypersensitivity (DTH) assay. In H-2 compatible combinations, Mls-locus antigens, but no other minor histocompatibility antigens, can induce the generation of such effector T cells.

Influence of 2'-deoxyguanosine upon the development of DTH effector T cells and suppressor T cells in vivo.

Subcutaneous (s.c.) immunization of mice with allogeneic spleen cells can induce delayed-type hypersensitivity (DTH) to both major and minor histocompatibility antigens.

Specific and nonspecific T-cell-mediated suppression of antihost immune reactivity in graft-versus-host reaction.

Intravenous immunization of mice with irradiated (2000 rads) allogeneic lymphoid cells induces the generation of suppressor T cells. Such suppressor T cells are capable of suppressing the antihost immune reactivity during acute and delayed graft-versus-host reactions. These suppressor T cells are strictly antigen-specific as far as their activation is concerned, but also suppress the reaction against unrelated antigens presented by the irradiated host.