Publications by authors named "B D Hancock"
Nurses comprise the largest group of health professionals yet are underrepresented in health news media, depriving the public of important perspectives on health and healthcare and undermining the public's perceptions of nurses as experts. The George Washington University School of Nursing's Center for Health Policy and Media Engagement partnered with the American Organization for Nursing Leadership to invite a small group of chief nursing officers to participate in a workshop aimed at building an organization-specific strategy for sharing nurses' expertise with the public through media engagement. Participants completed a preworkshop survey, participated in two 4-hour workshops to explore the factors that contribute to nurses' invisibility as media sources, and developed a strategic plan for ensuring that their healthcare organizations are able to recognize and share their nurses' expertise with media.
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- Oyster reefs are vital but endangered habitats that support ecosystem services and biodiversity, particularly for the flat oyster (Ostrea angasi) in Australia.
- Research in southeast Tasmania focused on relationships between community respiration, nitrogen fluxes, filtration rates, and oyster and sediment characteristics across three sites, finding significant positive correlations with live oyster biomass.
- The study indicated that Ralphs Bay, with the most intact reef, had higher community respiration and biodiversity, while sediment's organic and silt content had minimal effects, emphasizing the importance of oyster biomass for improving water quality and ecosystem health.
Introduction: NK cells can mediate tumor cell killing by natural cytotoxicity and by antibody-dependent cell-mediated cytotoxicity (ADCC), an anti-tumor mechanism mediated through the IgG Fc receptor CD16A (FcγRIIIA). CD16A polymorphisms conferring increased affinity for IgG positively correlate with clinical outcomes during monoclonal antibody therapy for lymphoma, linking increased binding affinity with increased therapeutic potential via ADCC. We have previously reported on the FcγR fusion CD64/16A consisting of the extracellular region of CD64 (FcγRI), a high-affinity Fc receptor normally expressed by myeloid cells, and the transmembrane/cytoplasmic regions of CD16A, to create a highly potent and novel activating fusion receptor.
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- Two new anhydrous forms of the antiviral drug nirmatrelvir were identified during the development of Paxlovid, Pfizer's COVID-19 treatment, labeled as Forms 1 and 4.
- A combination of experimental and computational techniques was used to differentiate these closely related polymorphs, including X-ray diffraction, thermal analysis, and molecular dynamics simulations.
- Form 1 was found to be the more stable polymorph at temperatures above 17 °C, highlighting the effective use of diverse methods in speeding up drug development during the pandemic.