Clinicomycological Profile of Dermatophytosis in Tripura - An Institution Based Cross Sectional Study.

Background: In a small state like Tripura, a surge in prevalence of superficial dermatophytosis has been observed from April to September among the population of both tribal and non-tribal groups having different lifestyle, different food habit, and different socioeconomic status. Studies from different region reveal varying pattern of etiological distribution of the disease. But till date no research study has been initiated in Tripura on clinicomycological profile of dermatophytosis.

Haematological parameters as predictors of severe dengue: a study from northern districts of West Bengal.

Background Objectives: A hike in dengue cases was recorded in last two years, resulting from both single and multiple-serotypes of dengue virus (DENV) and secondary infections, culminating in significant hospitalizations and deaths in India. This study focuses on evaluating symptomatic and haematological parameters in acute dengue patients of the northern part of West Bengal to predict disease severity early on and also to analyze the correlation between circulating DENV serotypes with severity.

Methods: Dengue patients (N=540) diagnosed as NS1 positives were categorized into 13.

Repurposing of DrugBank molecules as dual non-hydroxamate HDAC8 and HDAC2 inhibitors by pharmacophore modeling, molecular docking, and molecular dynamics studies.

HDAC8 and HDAC2 are recently reported to be overexpressed in cervical cancer. To date, studies related to the use of dual targeted HDAC inhibitor to treat cervical cancer are not well explored. Again, majority of the selective HDAC inhibitors discovered so far are hydroxamic acids, which have multiple adverse side-effects due to their strong zinc chelating ability.

Fixation of CO with Epoxides Catalyzed by Pincer-Type Azo-Aromatic Complexes of Cobalt as Catalysts.

Employing a series of azo-aromatic pincer-type cobalt(II) complexes, -, and an imine-based cobalt complex, , a highly efficient catalytic protocol for the cycloaddition of CO with epoxides at low pressure of CO is reported. The electron-withdrawing group-substituted ligands containing complexes and were most efficient. The catalytic protocol with involved a synergistic participation of an azo-aromatic catalyst (0.

The Legacy of James Marion Sims: History Revisited.

The title "Father of Modern Gynecology" is often attributed to Dr James Marion Sims, a pioneering American physician whose contributions to gynecology have profoundly influenced modern medical practice. Born in 1813, Sims developed several innovative surgical techniques and instruments that revolutionized the treatment of gynecological conditions. Among his most notable contributions is the Sims speculum, which remains a fundamental tool in gynecological examinations today.