Publications by authors named "B D Coller"

Professor Richard Klein and his students built a bicycle with a rather interesting feature: no one was able to ride it. A prize was offered. Hundreds of students and cycling enthusiasts attempted it.

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rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination.

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Article Synopsis
  • Platelet clot retraction plays a crucial role in stabilizing clots and requires functional αIIbβ3 receptors and fibrin, along with the platelet cytoskeleton's contractile activity.
  • Recent research found that even when platelet aggregation is blocked using the αIIbβ3 antagonist RGDW, clot retraction still occurs, leading to the development of a high-throughput assay to identify small molecule inhibitors of this process.
  • A screening of over 9,700 compounds revealed 27 inhibitors of clot retraction, including established antiplatelet drugs and new compounds, with further studies suggesting these may have unique mechanisms to inhibit thrombosis.
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Acute myocardial infarction still represents the major cause of mortality in high-income countries. Therefore, considerable efforts have been focused on the treatment of myocardial infarctions in the acute and long-term phase, with special attention being paid to reperfusion strategies and adjunctive antithrombotic therapies. In fact, despite the successful mechanical recanalization of the epicardial conduit, a substantial percentage of patients still experience poor myocardial reperfusion or acute/subacute in-stent thrombosis.

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Background: One recent trend in medical education is the integration of humanities into the curriculum, including viewing works of art in museums, with analysis of short-term, but not long-term, impact. We developed a course for medical students, trainees, and faculty at the Icahn School of Medicine at Mount Sinai co-taught by an art historian and a physician/medical historian that features images of great works of art to make connections between art and medical history with the following goals: 1. To encourage the students to make careful and systematic observations, describe what they see to others in the group, and exchange their views respectfully, 2.

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