Effects of an Oral Nutritional Supplementation and Physical Exercise Intervention on Older Adults at Risk for Sarcopenia.

Objectives: Sarcopenia is a skeletal muscle mass (SMM) disease characterized by loss of strength with generalized loss of SMM. The aim of this study is to evaluate the effects of a 12-week intervention on SMM, strength, and functionally in older adults.

Methods: This is a retrospective analysis of an intervention protocol with older adults at risk of sarcopenia who performed a daily intake of oral nutritional supplements (ONS) and resistance training exercise (RET), 3 times a week.

European expert consensus recommendations on the primary care use of direct oral anticoagulants in patients with venous thromboembolism.

Background: Direct oral anticoagulants for the treatment of venous thromboembolism are supported by robust clinical trial evidence. Despite published guidance, general practitioners are faced with increasingly complex decisions and implementation remains sub-optimal in certain real-world scenarios.

Methods: A two stage formal consensus exercise was performed to formulate consensus statements and a summary guide, facilitating optimal management of direct oral anticoagulants in venous thromboembolism patients by generalist physicians across Europe.

Bone strength is reduced in a neonatal androgenized rat model.

Background: Whether polycystic ovary syndrome (PCOS) affects bone health during a woman's lifespan remains controversial. An androgenized rodent model replicated many metabolic and reproductive features of women with PCOS, and we aimed to use it to investigate the impact of androgens on microarchitecture (by micro-CT), bone mechanical strength, bone formation and resorption markers in rats with intact ovaries (SHAM) who underwent oophorectomy.

Methods: Wistar rats ( were employed for the experiments in this study.

The slow rate of working memory consolidation from vision is a structural limit.

The speed with which information from vision is transformed into working memory (WM) representations that resist interference from ongoing perception and cognition is the subject of conflicting results. Using distinct paradigms, researchers have arrived at estimates of the consolidation time course ranging from 25 ms to 1 s - a range of more than an order of magnitude. However, comparisons of consolidation duration across very different estimation paradigms rely on the implicit assumption that WM consolidation speed is a stable, structural constraint of the WM system.