Influence of substrate stiffness on the phenotype of heart cells.

Adult cardiomyocytes (CM) retain little capacity to regenerate, which motivates efforts to engineer heart tissues that can emulate the functional and mechanical properties of native myocardium. Although the effects of matrix stiffness on individual CM have been explored, less attention was devoted to studies at the monolayer and the tissue level. The purpose of this study was to characterize the influence of substrate mechanical stiffness on the heart cell phenotype and functional properties.

Medico-legal investigation of suspected fatal poisonings in Pretoria: 2000-2001.

Accurate data on the incidence and spectrum of fatal poisonings in South Africa is lacking. Most studies focus on "traditional poisons". This is a retrospective study on the medico-legal investigation of suspected fatal poisonings seen at the Pretoria Medico-Legal Laboratory.

An unusual missile-type head injury caused by a stone: case report and medicolegal perspectives.

Missile head injury is predominantly caused by firearms; however, small blunt objects such as a stone can be propelled into the air and cause a low-velocity-type missile injury, as described in this case report. Since the cerebral damage in low-velocity missile injuries is usually focal, there might not be disturbance of consciousness until secondary brain damage occurs; therefore, adequate medical supervision is necessary to prevent and treat potentially fatal complications in a timely manner. This is a rare case of a penetrating missile wound of the head, most likely caused by the use of a stone propelled by a slingshot that penetrated the skull and lacerated the brain with the stone embedded within the substance of the brain.

Fatal firearm wounds: a clinicopathologic study.

Firearm-related injuries are a leading cause of morbidity and mortality in South Africa. This retrospective autopsy study included all firearm-related fatalities seen at a central mortuary in Durban. These cases had initially been assessed by a clinician before death, from July 1998 to June 1999.

Custody-related deaths in Durban, South Africa 1998-2000.

Custody-related deaths have become a major human rights issue in South Africa since the 1994 democratic elections and led to the formation of the Independent Complaints Directorate who, in April 2000, had recorded 2174 custody-related deaths since their inception. A 3-year retrospective descriptive study on all custody-related death cases at a Durban Medico-legal mortuary from January 1998 to December 2000 was undertaken. The study included deaths that occurred during arrest and deaths within the South African Police Services holding cells.