Management of Pelvic Pain in Patients with Crohn's Disease-Current Overview.

Crohn's disease (CD) is a subtype of chronic inflammatory bowel diseases (IBD) with characteristic skip lesions and transmural inflammation that may affect the entire gastrointestinal tract from the mouth to the anus. Persistent pain is one of the main symptoms of CD. This pain has multifactorial pathogenesis, but most often arises from intestinal inflammation itself, as well as from gut distention or partial intestinal obstruction.

Short-chain fatty acids-microbiota crosstalk in the coronavirus disease (COVID-19).

The novel coronavirus disease (COVID-19) still remains a major challenge to the health-care systems worldwide, inciting ongoing search for pharmaceutical and non-pharmaceutical interventions which could benefit patients already infected with SARS-CoV-2 or at increased risk thereof. Although SARS-CoV-2 primarily affects the respiratory system, it may also infect other organs and systems, including gastrointestinal tract, where it results in microbial dysbiosis. There is an emerging understanding of the role the gut microbiota plays in maintaining immune homeostasis, both inside the gastrointestinal tract and beyond (i.

Oxygen Binding by Co(II) Complexes with Oxime-Containing Schiff Bases in Solution.

The present work describes the complexation properties of two oxime-containing Schiff bases (used as ligands), viz. 2-hydroxyimino-N'-[1-(2-pyridyl)ethylidene]propanohydrazone (Hpop) and 2-hydroxyimino-N'-[(pyridine-2-yl)methylidene]propanohydrazone (Hpoa), with Co(II) ions in DMSO/water solution. Volumetric (oxygenation) studies were carried out to determine the uptake of molecular oxygen O in the formation of the complexes Co(II)-Hpop and Co(II)-Hpoa.

Hypervelocity cluster ion impacts on free standing graphene: Experiment, theory, and applications.

We present results from experiments and molecular dynamics (MD) simulations obtained with C and Au impacting on free-standing graphene, graphene oxide (GO), and graphene-supported molecular layers. The experiments were run on custom-built ToF reflectron mass spectrometers with C and Au-LMIS sources with acceleration potentials generating 50 keV C and 440-540 keV Au . Bombardment-detection was in the same mode as MD simulation, i.

Ejection-ionization of molecules from free standing graphene.

We present the first data on emission of C60- stimulated by single impacts of 50 keV C602+ on the self-assembled molecular layer of C deposited on free standing 2 layer graphene. The yield, Y, of C60- emitted in the transmission direction is 1.7%.