Publications by authors named "B Czako"
Article Synopsis
- Autoimmune pancreatitis (AIP) is often mistaken for pancreatic cancer, making diagnosis difficult, especially in cases requiring surgical intervention like pancreatic resection.
- A meta-analysis reviewed 10 studies, finding that 1.6% (140 cases) of patients who underwent pancreatic resection for suspected cancer actually had AIP, with 94% being type 1 AIP.
- The study highlights that current diagnostic methods are inadequate, as serum CA 19-9 levels do not effectively differentiate between AIP and pancreatic ductal adenocarcinoma (PDAC), leading to the risk of unnecessary surgeries.
The coronavirus disease 2019 pandemic had a major impact on most medical services. Our aim was to assess the outcome of acute cholecystitis during the nationwide lockdown period. All patients admitted to our emergency department for AC were analysed.
View Article and Find Full Text PDFPervasive neuroinflammation occurs in many neurodegenerative diseases, including Alzheimer's disease (AD). SPI1/PU.1 is a transcription factor located at a genome-wide significant AD-risk locus and its reduced expression is associated with delayed onset of AD.
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- Cancers with a specific enzyme deletion (ENO1) are sensitive to treatment targeting a related enzyme (ENO2).
- Previous studies showed promise with a specific inhibitor (HEX) that can shrink tumors in certain models of glioblastoma.
- This research aimed to find better prodrug options (forms that release the active drug) for ENO2 inhibition, assessing different types that could be more effective and stable in the bloodstream.
The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca-triggered neurotransmitter release in neuronal synapses. The interacting residues of the primary interface are conserved across different species for synaptotagmins (Syt1, Syt2, Syt9), SNAP-25, and syntaxin-1A homologs involved in fast synchronous release. This Ca-independent interface forms prior to Ca-triggering and plays a role in synaptic vesicle priming.
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