Publications by authors named "B Crescenzi"
Article Synopsis
- Jumping translocations (JT), linked to disease progression in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), involve the movement of a tri-tetra-somic 1q chromosome to various other chromosomes.
- Research showed that in patients with SRSF2 mutations, JT was associated with changes in DNA methylation during treatment with 5'-azacytidine (AZA), revealing significant shifts in the methylome and impacting various biological pathways.
- The study highlighted that epigenetic modifications, including changes in DNA methylation and specific signaling pathways like PI3K/AKT and MAPK, play a crucial role in the progression of myeloid neoplasms associated with
Article Synopsis
- - Acquired aplastic anemia (AA) is a rare condition involving low blood cell counts and underdeveloped bone marrow, affecting 2-3 people per million in Western countries and more in East Asia.
- - Treatments for severe aplastic anemia (SAA) have improved significantly, with hematopoietic stem cell transplantation (HSCT) from a matched sibling donor considered the best first-line approach, although alternatives exist if a sibling donor isn't available.
- - A guideline developed by pediatric hematologists aims to assist healthcare professionals in diagnosing and managing AA in children, based on evidence gathered and discussions held during consensus conferences, including adaptations made due to the COVID-19 pandemic.
Article Synopsis
- Scientists found a new type of genetic change called t(X;21) in some patients with blood diseases like myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
- This change happened along with other mutations in certain genes, but it didn't create new fusion genes as might be expected.
- They discovered that this genetic change is linked to the loss of two important genes (BCOR and RUNX1), which affects how cells behave in these diseases.
Mantle cell lymphoma is a B-cell malignancy, which, in its classic form, usually involves lymph nodes and extranodal sites, and, among the extranodal sites, the gastrointestinal tract and the Waldeyer's ring are most prevalent. MCL is rarely reported in the ocular adnexa, a site more frequently affected by extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which is a form of low-grade malignancy. The diagnosis of MCL presenting in the ocular adnexa requires special attention as its rarity in this location combined with the not uncommon CD5 negativity of the disease when occurring in the ocular adnexa, may lead the pathologist to overlook the diagnosis and misinterpret MCL as marginal zone B cell lymphoma, which has a totally different behavior.
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