Publications by authors named "B Corradetti"
Background: Cognition is a research priority for people living with chronic kidney disease (CKD), but identification of critical research questions is lacking. This study aimed to determine which cognition-related research questions are most important to CKD stakeholders.
Methods: A modified Delphi technique with 3 survey rounds was used.
Article Synopsis
- Mesenchymal stem cells (MSCs) from gestational tissues are promising for treating congenital malformations but face challenges like invasiveness, prompting the exploration of less risky alternatives like naturally occurring exosomes (EXOs) and their mimics (MIMs) from amniotic fluid-derived MSCs (AF-MSCs).
- The study involved creating MIMs, comparing their properties to EXOs, and evaluating their safety and distribution in a mouse model predisposed to neural tube defects.
- Results indicated that MIMs and EXOs have similar characteristics, with MIMs yielding three times more product, and no adverse effects were found in pregnant mice, making MIMs a promising, minimally invasive therapeutic option.
Background: Mesenchymal stem cells (MSCs) from gestational tissues represent promising strategies for treatment of congenital malformations, but plasticity and required high-risk surgical procedures limit their use. Here we propose natural exosomes (EXOs) isolated from amniotic fluid-MSCs (AF-MSCs), and their mimetic counterparts (MIMs), as valid, stable, and minimally invasive therapeutic alternatives.
Methods: MIMs were generated from AF-MSCs by combining sequential filtration steps through filter membranes with different porosity and size exclusion chromatography columns.
The environment created during embryogenesis contributes to reducing aberrations that drive structural malformations and tumorigenesis. In this study, we investigate the anti-cancer effect of mesenchymal stem cells (MSCs) derived from 2 different gestational tissues, the amniotic fluid (AF) and the chorionic villi (CV), with emphasis on their secretome. Transcriptomic analysis was performed on patient-derived AF- and CV-MSCs collected during prenatal diagnosis and identified both mRNAs and lncRNAs, involved in tissue homeostasis and inhibiting biological processes associated with the etiology of aggressive cancers while regulating immune pathways shown to be important in chronic disorders.
View Article and Find Full Text PDFBackground: Living donor kidney transplantation (LDKT) is the optimal treatment for eligible patients with kidney failure, although it is underutilized. Contextually tailored patient- and family-centered interventions may be effective to increase LDKT.
Objective: We outline a protocol to test the feasibility of the Multidisciplinary Support To Access living donor Kidney Transplant (MuST AKT) intervention designed to increase LDKT.