Publications by authors named "B Copley"
Article Synopsis
- The study surveyed 2,661 breast cancer patients in Chicago between July and September 2020 to assess their psychosocial well-being and any financial challenges or treatment disruptions during the COVID-19 pandemic.
- Findings revealed increased feelings of isolation among patients, with about one-third facing financial issues, particularly affecting Black Medicaid recipients, and 25% having difficulties accessing treatment.
- The research highlights the negative impact of the pandemic on the quality of life for patients with breast cancer and calls for greater support from medical centers and the research community during these challenging times.
Racial disparities in survival outcomes among breast cancer patients by molecular subtypes.
Breast Cancer Res Treat
February 2021
Article Synopsis
- The study investigates the breast cancer mortality gap between White and Black patients, emphasizing the impact of tumor biology, genomic factors, and healthcare disparities.
- Researchers analyzed a cohort of 2795 breast cancer patients to assess five survival outcomes, using controlled models to compare Black and White patients.
- Findings indicate that Black patients generally have worse survival outcomes in all categories studied, with the most significant disparities observed in the HR-/HER2+ and HR+/HER2- breast cancer subtypes.
Sixty-six renal transplant patients maintained on Sandimmune, the traditional formulation of cyclosporine, participated in an open-label, sequential trial to compare intrapatient variability in drug exposure before and after a switch to Neoral. Three 12-hour cyclosporine pharmacokinetic profiles were obtained over approximately 6 weeks while patients were receiving Sandimmune. Patients were then switched to Neoral, with the dose adjusted as necessary to maintain target trough blood cyclosporine concentrations.
View Article and Find Full Text PDFCyclosporine-induced hypertension: evidence for maintained baroreflex circulatory control.
J Heart Lung Transplant
June 1997
Background: The clinical use of cyclosporine as an immunosuppressive agent enhanced long-term survival in transplant recipients at the expense of a high incidence of induced hypertension. Altered neurovegetative (autonomic) cardiovascular control is suspected as a mechanism of this form of hypertension.
Methods: Spectral analysis of systolic arterial pressure and R-R interval variability (electrocardiographic recordings) were performed, and the index alpha of baroreflex gain was computed in four groups of subjects matched for age: 13 orthotopic heart transplant recipients; 13 solid organ transplant recipients; 13 patients with essential hypertension; and 18 control subjects with normal blood pressure.