Publications by authors named "B Conradt"
Article Synopsis
- The CMG helicase complex is essential for controlling gene expression during asymmetric cell divisions in C. elegans.
- The specific component PSF-2 GINS2 is necessary for activating the pro-apoptotic gene egl-1, which is crucial for programmed cell death.
- The study highlights CMG's role in influencing cell fates and suggests it affects gene expression beyond just egl-1 regulation.
Various types of cell death program are needed for cells to respond to changes in physiological conditions. In this collection of Voices, we asked scientists to tell the story behind their contributions to the identification and mechanistic dissection of cell death pathways and to discuss future directions for such research.
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- During development, out of 1090 somatic cells generated, 131 undergo apoptosis, primarily regulated by the BH3-only gene, which activates cell death in specific lineages.
- The expression of this gene is controlled both transcriptionally and post-transcriptionally, with miR-35 and miR-58 miRNAs helping to repress it in cases of 'unwanted' cells.
- Through identifying RNA-binding proteins like EIF-3.H and HRPR-1 as potential activators of the gene, the study shows that knocking down these genes leads to the survival of undesired cells, illuminating how cell death patterns are established in development.
Mitochondria are the powerhouses of cells, responsible for energy production and regulation of cellular homeostasis. When mitochondrial function is impaired, a stress response termed mitochondrial unfolded protein response (UPRmt) is initiated to restore mitochondrial function. Since mitochondria and UPRmt are implicated in many diseases, it is important to understand UPRmt regulation.
View Article and Find Full Text PDFDuring C. elegans development, 1090 somatic cells are generated, of which 959 survive and 131 die, many through apoptosis. We present evidence that PUF-8, a C.
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