Publications by authors named "B Connor"
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder traditionally characterized by the selective loss of medium spiny neurons in the basal ganglia. However, it has become apparent that white matter injury and oligodendrocyte dysfunction precede the degeneration of medium spiny neurons, garnering interest as a key pathogenic mechanism of HD. Oligodendrocytes are glial cells found within the central nervous system involved in the production of myelin and the myelination of axons.
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- Pressure recovery can lead to inaccurately high aortic valve gradients when measured using Doppler echo.
- This effect is more significant after the replacement of a prosthetic aortic graft.
- When Doppler gradients don't match a patient's symptoms, a catheter-based assessment is recommended for a more accurate evaluation.
Article Synopsis
- - Huntington's disease (HD) is a genetic disorder that leads to the loss of specific neurons in the brain, causing motor dysfunction, and researchers are exploring cell replacement therapies to restore neuronal function.
- - The study focuses on creating human lateral ganglionic eminence precursors (hiLGEPs) from adult human skin cells through a process called direct reprogramming, which was evaluated for its ability to differentiate into functional neurons.
- - Results showed that hiLGEPs could be successfully produced and transplanted into rats with HD-like symptoms, demonstrating their potential to survive, integrate, and contribute to neuronal function over a 14-week period.
Article Synopsis
- The COVID-19 pandemic highlighted the urgent need for effective triage tools in healthcare to identify patients vulnerable to severe infections.
- Researchers studied COVID-19 patients at multiple sites, analyzing plasma markers to link their levels to mortality and severity of illness within set timeframes.
- Their findings showed higher suPAR levels correlated with increased mortality risk and severity, supporting the use of specific biomarkers like suPAR and sTREM-1 for better patient triage and hospital resource management.
Impact of an Adult Congenital Heart Disease Order Set in a Pediatric Cardiac Intensive Care Unit.
World J Pediatr Congenit Heart Surg
October 2024
Patients with congenital heart disease (CHD) are increasingly surviving to adulthood. Given their age- and condition-specific needs, the optimal postoperative setting for these patients is not yet determined. This study aims to evaluate the utility of an adult-specific order set in improving clinical outcomes for these patients in a pediatric cardiovascular intensive care unit (ICU).
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