Publications by authors named "B Cochran"
Article Synopsis
- Anti-GD2 antibody therapy offers benefits for neuroblastoma patients, but its effectiveness is limited by the tumor's immunosuppressive environment.
- Research shows that using copper chelation can enhance this therapy by improving immune responses, specifically by boosting the activity of neutrophils that help fight the tumor.
- The study suggests repurposing the approved copper chelator Cuprior as a safe and effective method to improve the outcomes of anti-GD2 therapy in neuroblastoma patients.
Article Synopsis
- Heart failure is prevalent among hemodialysis patients, and high flow arteriovenous fistulas (AVFs) may be a risk factor; this study aims to create a predictive model to identify patients at risk of developing high flow AVFs.
- Using data from 366 patients, the study compared various machine learning models to predict high flow AVF development, finding that the bootstrap forest model was the most effective.
- Results showed that while 31.4% of patients had high flow AVFs, and 24.9% developed heart failure after AVF creation, no direct correlation was found between AVF flow and the onset of heart failure or death post-creation.
This case discusses a 55-year-old patient who was evaluated at a dermatology outpatient clinic for a chronic, pruritic, and painful hyperkeratotic plaque located on her scalp vertex. Given the size of the plaque and its thick, yellow scales, an initial clinical diagnosis of seborrheic dermatitis was favored. However, after weeks of unsuccessful treatment with ketoconazole shampoo, topical fluocinolone 0.
View Article and Find Full Text PDFDupilumab, a systemic injectable biologic, can be prescribed to patients with atopic dermatitis who do not respond to topical treatments. Atopy can frequently subside by blocking inflammatory pathways, such as interleukin-4 (IL-4) and interleukin-13 (IL-13) in the immune system. Dupilumab is generally well-tolerated and mild; the most common adverse reactions listed are arthralgia, back pain, and conjunctivitis, which clears upon cessation or finalization of dupilumab therapy.
View Article and Find Full Text PDFArticle Synopsis
- Phytophotodermatitis is a skin reaction caused by contact with plant chemicals (furocoumarins) and sunlight exposure, observed in a case study of a 34-year-old patient post-beach trip in Mexico.
- The patient's irregular hyperpigmented patch developed after handling lime during a margarita, linking the skin issue to both sun and citrus exposure.
- This case emphasizes the need for detailed patient history and examination to avoid misdiagnosis and inappropriate treatments for skin conditions that may appear similar.