Publications by authors named "B Cirovic"
Leukemia stem cells (LSCs) are widely believed to reside in well-characterized bone marrow (BM) niches; however, the capacity of the BM niches to accommodate LSCs is insufficient, and a significant proportion of LSCs are instead maintained in regions outside the BM. The molecular basis for this niche-independent behavior of LSCs remains elusive. Here, we show that integrin-α9 overexpression (ITGA9 OE) plays a pivotal role in the extramedullary maintenance of LSCs by molecularly mimicking the niche-interacting status, through the binding with its soluble ligand, osteopontin (OPN).
View Article and Find Full Text PDFArticle Synopsis
- Hematopoiesis is the process where the body makes more blood and immune cells when it's fighting infections or dealing with stress.
- Scientists studied how certain mouse blood cells called hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) help in this process during a severe infection called polymicrobial sepsis.
- They found that while HSCs increased in number and died off, they didn't change much in how they turned into other blood cells; instead, MPPs played a big role in quickly making more immune cells.
Naked mole-rats (NM-R; ) live in multi-generational colonies with a social hierarchy, and show low cancer incidence and long life-spans. Here we asked if an immune component might underlie such extreme physiology. The largest lymphoid organ is the spleen, which plays an essential role in responding to immunological insults and may participate in combating cancer and slowing ageing.
View Article and Find Full Text PDF