Publications by authors named "B Cinque"
Skin aging is characterized by reactive oxygen species (ROS) accumulation, principal players in triggering events associated with aging. Our recent data on the ability of an innovative poly-component formulation (KARISMA Rh Collagen FACE: K formulation) to suppress the biomolecular events associated with oxidative stress-induced aging prompted us to deepen the mechanisms underlying the observed effects on aged human dermal fibroblasts (HDFs). Here, we evaluated K's ability to perform a direct free radical-scavenging action and modulate anti-oxidant systems by counteracting the inflammatory process in an HO-induced cellular senescence model.
View Article and Find Full Text PDFSkin aging is influenced by intrinsic and extrinsic factors that progressively impair skin functionality over time. Investigating the skin aging process requires thorough research using innovative technologies. This review explores the use of in vitro human 3D culture models, serving as valuable alternatives to animal ones, in skin aging research.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how certain drugs used to treat inflammatory bowel disease (IBD) affect intestinal fibrosis, a condition not yet effectively treatable.
- Researchers examined the impact of medications like prednisone, methylprednisolone, budesonide, and adalimumab on key processes that contribute to intestinal fibrosis and epithelial-to-mesenchymal transition (EMT).
- Findings indicate that these drugs can counteract TGF-β1-induced fibrosis and EMT in intestinal cells, suggesting their potential for antifibrotic therapy in IBD.
Protective effects of fatty acid amide hydrolase inhibition in UVB-activated microglia.
Biochim Biophys Acta Mol Cell Biol Lipids
October 2024
Neuroinflammation is a hallmark of several neurodegenerative disorders that has been extensively studied in recent years. Microglia, the primary immune cells of the central nervous system (CNS), are key players in this physiological process, demonstrating a remarkable adaptability in responding to various stimuli in the eye and the brain. Within the complex network of neuroinflammatory signals, the fatty acid N-ethanolamines, in particular N-arachidonylethanolamine (anandamide, AEA), emerged as crucial regulators of microglial activity under both physiological and pathological states.
View Article and Find Full Text PDFBackground: Enamel plays an essential role in protecting the underlying layers of the human tooth; therefore, preserving it is vital. This experimental study aimed to evaluate the potential ability of to counteract the action of a demineralizing agent on dental enamel morphology and mineral composition in vitro.
Methods: The sample consisted of 12 healthy human posterior teeth.