Publications by authors named "B Chowdhury"
Background Diabetes mellitus, characterized by chronic hyperglycemia, often leads to severe hepatic dysfunction, including increased liver enzyme levels and histopathological changes in the liver. Streptozotocin (STZ)-induced diabetic rat models provide a valuable method for evaluating potential therapeutic agents that target hepatic complications. , a medicinal plant with known anti-diabetic properties, has been used traditionally for its hepatoprotective effects, although scientific evidence is limited.
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- * Research reveals that the CD225 domain harbors a SNARE-like motif, enabling interactions with SNARE proteins, which are essential for membrane fusion; this is particularly important in diseases linked to mutations in these regions, such as neurological disorders.
- * One member, IFITM3, is shown to interact with SNARE proteins to protect against influenza A virus by disrupting SNARE complex assembly and enhancing endosomal cargo movement to lysosomes, suggesting a key role for SNARE modulation in the diverse functions of CD225
Objectives: Determine the improvements in outcomes of transsphenoidal pituitary adenoma resection following addition of a skull base rhinologist to the neurosurgical team.
Design: All patients that underwent transsphenoidal resection of pituitary adenoma were identified. Demographic data, Otolaryngology (ENT) involvement, initial adenoma size, extent of resection, hormonal secretion status, visual field exam, post-operative DI, CSF leak, recurrence, need for nasoseptal flap (NSF), re-operation rate were all collected.
Article Synopsis
- The study investigates the use of ketorolac, an NSAID, for managing postoperative pain in patients after craniotomy for tumor resection, focusing on its impact on pain control, bleeding risks, and narcotic use.
- A review of 1114 adult patients revealed that those receiving ketorolac were younger and had lower comorbidities, yet did not show a significantly higher rate of bleeding compared to those who did not receive the drug.
- Patients on ketorolac experienced higher initial pain and opioid use, but overall, it was found to be a safe and effective pain management choice after surgery, suggesting the need for further research to confirm these findings.
Arterial thrombosis is a leading cause of death and disability worldwide with no effective bioassay for clinical prediction. As a symbolic feature of arterial thrombosis, severe stenosis in the blood vessel creates a high-shear, high-gradient flow environment that facilitates platelet aggregation towards vessel occlusion. Here, we present a thrombus profiling assay that monitors the multi-dimensional attributes of thrombi forming in such biomechanical conditions.
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