Hyperlipidemia, dyslipoproteinemia and apolipoproteinopathia--classification and risk of atheroslcerosis. Part I: Principles of classification and methods of dyslipoproteinemia determination.

This paper sums up new findings in the field of pathogenetic relations between lipid and lipoprotein metabolical disorders on the one hand and the risk of early forms of atherosclerosis on the other hand. Detail classification of disorders proceeds from precise clinical and biochemical criteria, genetic considerations and therapeutical aspects. It provides definitions of hyperlipidemia, hyperlipoproteinemia, normolipidemic (latent) dyslipoproteinemia, secondary hyperlipidemia, apolipoproteinopathia and relatively harmless (benign) hyperlipidemia.

Hyperlipidemia, dyslipoproteinemia and apolipoproteinopathia--classification and risk of atherosclerosis. Part 5: Normolipidemic (latent) dyslipoproteinemia.

The last chapter deals with the normalipidemic (latent) dyslipoproteinemias, their pathobiochemistry, clinical aspects and the risk of atherosclerosis. In conclusion, the authors sum up the more recent views on the dysbalance of prostaglandins in relation to the cardiovascular diseases, the functions of the vascular wall and blood paletets in atherogenesis.

Hyperlipidemia, dyslipoproteinemia and apolipoproteinopathia--classification and risk of atherosclerosis. Part 4: Apolipoproteinopathia.

The article defines apolipoprotein diseases as the structural defects of apolipoproteins or disorders in their synthesis or secretion. The survey covers a range of atherogenous defects, providing a detailed description of their clinical-biochemical and genetic aspects as well as diagnostic and differential diagnostic criteria. Attention is paid also to the significance of analytical isoelectric focusing.

Hyperlipidemia, dyslipoproteinemia and apolipoproteinopathia--classification and risk of atherosclerosis. Part 3: Hypertriacylglycerolemia.

The authors classify hypertriacylglycerolemias according to their relationship with atherosclerosis as disorders with and without chylomicronemia, atherogenous disorders with an increased level of apolipoprotein B in the VLDL fraction, and relatively harmless (benign) cases. They single out the remarkable heterogeneity of hypertriacylglycerolemias and their epidemiological aspects. The analysis of the various disorders comes complete with their pathobiochemistry and the clinic-biochemical criteria of their classification.

Hyperlipidemia, dyslipoproteinemia and apolipoproteinopathia--classification and risk of atherosclerosis. Part 2: Hypercholesterolemia.

This paper sums up recent intervention epidemiological studies of primary atherogeneous hypercholesterolemias. The authors include in this category familial hypercholesterolemia, familial combined hyperlipidemia, and polygenous hypercholesterolemia. Individual disorders are thoroughly analyzed in view of their early diagnostics, differential diagnostics and clinical state.