The role of the mGluR allosteric modulation in the NMDA-hypofunction model of schizophrenia.

Schizophrenia is one of the most important forms of psychiatric illness and may be chronic and highly disabling. It has been suggested that specific neurochemical abnormality is due to dopaminergic overactivity in the brain. Schizophrenia is currently thought to be associated with a hypoglutamatergic state that is mimicked by acute Phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate (NMDA) receptor subtype.

Orexin-A induces long-term depression of nmda responses in CA-1 field of hippocampal slices.

We have studied the effects of orexin-A on NMDA component of registered field potentials in pyramidal (str. pyramidale) and radial layers (st. radiatum) of CA-1 field of the hippocampus.

The proper time for hearing screening in newborns.

The proper time for hearing screening in newborns via recordings of transiently evoked otoacoustic emission, TEOAE, has been estimated. 269 healthy neonates were investigated during five consecutive days after birth. On the first day, the results of screening were positive in 51 newborns only, 19.

[Age and changes in the latent periods of the slow human auditory potential].

Regular changes in latencies of slow auditory evoked potentials were found with age. In particular, peak-latencies of comparatively early deflections, i.e.