Publications by authors named "B Childs"
Background: Patients with large labral tears represent a subset of traumatic shoulder instability cases. Outcomes after arthroscopic stabilization in these patients have been studied less compared with other tears.
Purpose: To establish minimal clinically important difference (MCID), Patient Acceptable Symptom State (PASS), and substantial clinical benefit (SCB) thresholds for patients after arthroscopic repair of labral tears ≥270°.
The cost of healthcare is an issue of concern for both consumers and funders of healthcare in South Africa. The country spends approximately 8% of GDP on health care. Health care is financed through the public sector which covers 86% of the population and the private sector which covers 14% of the population.
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- HD-PTP (or PTPN23) plays a key role in the formation of multivesicular bodies by aiding endosomal sorting complexes, which is important for cellular transport.
- Researchers created mice with reduced HD-PTP levels to study its physiological effects, discovering these mice displayed lipodystrophy and impaired signaling in white adipose tissue related to various pathways, including RAS/MAPK and PI3K/AKT.
- The study found that while EGF binding was normal, there was reduced signaling activation due to changes in cholesterol distribution within cells, suggesting a crucial role for HD-PTP in both signaling regulation and maintaining fat tissue health.