Effect of konjac glucomannan aerogel-immobilized Chlorella vulgaris LH-1 on oil-contaminated seawater remediation and endogenous bacterial community diversity.

Ocean oil spills can severely impact ecosystems and disrupt marine biodiversity and habitats. Microbial remediation is an effective method for removing thin oil slick contamination. In this study, the adsorption and degradation of low-concentration oil spills by Chlorella vulgaris LH-1 immobilized in konjac glucomannan (KGM) aerogel were investigated.

Plays a Pivotal Role in Colorectal Cancer Progression via the Dual Regulation of Cell Cycle and Epithelial-Mesenchymal Transition.

Background: Cytoskeleton-associated protein 2 like () has been demonstrated to mediate the cell cycle in cancer cells. However, it is unknown whether CKAP2L impacts colorectal cancer (CRC). The purpose of this study was to investigate the role of in CRC.

Access to Chiral Bridged Biaryls via Brønsted Acid-Catalyzed Asymmetric Addition of Alcohols to Fluoroalkylated Biaryl Oxazepines.

We disclose herein a chiral phosphoric-acid-catalyzed enantioselective addition reaction of alcohols to fluoroalkylated biaryl 1,3-oxoazepines, which furnished a wide range of bridged biaryls bearing a fluoroalkylated quaternary carbon stereocenter on the seven-membered ring in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). Our method can be used for the modification of several natural products and bioactive molecules. Preliminary studies revealed that the products obtained in this reaction exhibit good in vitro bioactivities against two plant pathogens.

The potential of melatonin in sepsis-associated acute kidney injury: Mitochondrial protection and cGAS-STING signaling pathway.

Melatonin (Mel) is known for various biological function, such as antioxidant and anti-inflammatory capabilities, as well as its ability to modulate immune responses, which can protect mitochondria and improve the prognosis of sepsis-associated acute kidney injury (SA-AKI). However, there is a multitude of theories regarding how Mel exerts its immune-modulating functions, with no consensus reached as of yet. We propose the protective effects of Mel on mitochondria are closely related to the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway in the immune-inflammatory response.

A NIR fluorescent probe based on carbamoyl oxime with high specificity for detecting ferrous ions in food and in vivo.

Ferrous ions (Fe), the primary form of iron in cells, play a crucial role in various biological processes. The presence and absorption of Fe in food has an important impact on human health. Proper dietary intake and iron supplementation are conducive to prevent and treat iron-related diseases.