Publications by authors named "B Chaput"

Background: Reconstruction of the axillary fossa represents a surgical challenge given the functional implications for mobility of the upper limb. The posterior brachial flap is a solution of choice for this indication, providing fine and functional local reconstruction, but little is known about its perforasome. This study aimed to identify the location of the perforator, analyze perfusion flow, and link vessel distribution, and propose an aesthetic refinement to the surgical technique by medializing the skin paddle to conceal aesthetic scarring at the donor site.

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We report on using a pedicled posterior brachial perforator flap to cover a defect of the infraspinous fossa. The first description of the posterior brachial flap came from Masquelet in 1985, and there are very few reports of this flap in the literature, mainly in its pedicled form limited to axillary covers. Scapular soft tissue defect with bone exposure can be covered by several techniques.

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Article Synopsis
  • Skin healing is a multi-phase process involving inflammation, tissue reconstruction, and remodeling, where macrophages play a key role in transitioning from inflammation to repair.
  • Mesenchymal stromal cells derived from adipose tissue (ADSCs) are increasingly utilized for their regenerative properties, aiding in wound healing and providing immunomodulatory benefits.
  • Direct application of ADSCs and macrophages to wounds can face challenges like cell viability; hence, using biomaterials as scaffolds to enhance cell survival and function is being explored for better skin regeneration outcomes.
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  • Microsurgical free tissue transfer is critical for repairing significant bone or soft tissue injuries but is often seen as unfeasible in low- and middle-income countries due to the need for specialized training and resources.
  • A program in Cambodia, supported by non-governmental organizations, successfully performed 56 free flap surgeries from 2004 to 2023, training local surgeons while treating various reconstruction needs.
  • Despite facing a higher failure rate compared to high-income countries, the majority (83.3%) of patients showed improvement or complete resolution of their original issues, highlighting the potential for better outcomes with targeted solutions in low-resource settings.*
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  • Scientists are creating new ways to develop drugs and vaccines more effectively and safely before testing them on people.
  • A new system has been created to study how human skin reacts to immunogenic drugs, allowing researchers to see how the immune cells respond in detail.
  • The study looked at how the COVID-19 vaccine works in the body, showing how it affects different immune cells and helping to improve future vaccines and drug methods.
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