Publications by authors named "B Caughey"
ctDNA/MRD Testing for Colon Cancer: A Work in Progress or Ready for Prime-Time Standard of Care?
J Natl Compr Canc Netw
December 2024
In patients with surgically resectable colon cancer (CC), clinicopathologic characteristics translate into cancer staging and predict recurrence risk. Adjuvant chemotherapy reduces the risk of recurrence and is offered to high-risk patients. However, some patients are inevitably overtreated or undertreated; better risk stratification is necessary to improve outcomes after surgery.
View Article and Find Full Text PDFTargeting tumor-specific molecular alterations has shown significant clinical benefit. Molecular tumor boards (MTBs) connect cancer patients with personalized treatments and clinical trials. However, rural cancer centers often have limited access to MTB expertise.
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- Comprehensive genomic profiling (CGP) is commonly used to guide treatment for solid tumors and myeloid neoplasms, but its effectiveness for lymphoid and histiocytic cancers is less established.
- In a study of 105 CGP samples from patients with non-myeloid hematologic malignancies, 88% showed pathogenic mutations, with 72% of patients having mutations that could influence their treatment or prognosis.
- The study found that CGP led to a significant change in management for 22% of patients, particularly in cases where resistance variants were identified, affecting treatment decisions in nearly 70% of those cases.
Chronic wasting disease (CWD) is a widely distributed prion disease of cervids with implications for wildlife conservation and also for human and livestock health. The structures of infectious prions that cause CWD and other natural prion diseases of mammalian hosts have been poorly understood. Here we report a 2.
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