Publications by authors named "B Cauchoix"
Background: Post-exposure prophylaxis (PEP) using single-dose rifampicin reduces progression from infection with Mycobacterium leprae to leprosy disease. We compared effectiveness of different administration modalities, using a higher (20 mg/kg) dose of rifampicin-single double-dose rifampicin (SDDR)-PEP.
Methods: We did a cluster randomised study in 16 villages in Madagascar and 48 villages in Comoros.
The incidence rate of tuberculosis in prisons is estimated to be 8 times greater than that in the general population in Madagascar. Our objectives were to estimate the prevalence of pulmonary tuberculosis and HIV infection among prisoners and to identify risk factors associated with tuberculosis. We conducted a cross-sectional study at the central prison of Antananarivo from March to July 2021.
View Article and Find Full Text PDFObjectives: To identify patterns of spatial clustering of leprosy.
Design: We performed a baseline survey for a trial on post-exposure prophylaxis for leprosy in Comoros and Madagascar. We screened 64 villages, door-to-door, and recorded results of screening, demographic data and geographic coordinates.
Article Synopsis
- Human settlement in Madagascar began in the first millennium with migrations from Southeast Asia, Africa, and the Middle East, leaving cultural and genetic legacies.
- The study used whole-genome sequencing to analyze leprosy strains in Madagascar and the Comoros, identifying a new genotype (1D-Malagasy) prevalent in these regions and linked to local public health issues.
- Findings indicate that leprosy likely originated from later migrations from East Africa, the Middle East, or South Asia, rather than being introduced by the early Austronesian settlers.
Protocol, rationale and design of PEOPLE (Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar): a cluster randomized trial on effectiveness of different modalities of implementation of post-exposure prophylaxis of leprosy contacts.
BMC Infect Dis
December 2019
Background: Leprosy is an ancient infectious disease with a global annual incidence that has plateaued above 200,000 new cases since over a decade. New strategies are required to overcome this stalemate. Post-exposure prophylaxis (PEP) with a single dose of Rifampicin (SDR) has conditionally been recommended by the World Health Organization (WHO), based on a randomized-controlled-trial in Bangladesh.
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