Publications by authors named "B Castelo"
Anorectal dysfunctions (ARDs) include fecal incontinence (FI) and functional defecation disorders (FDDs). The pelvic floor muscles play a central role in the physiology of continence and defecation. We aimed to investigate the prevalence of sarcopenia in a female group with anorectal dysfunctions and compare them with a healthy female age-matched group.
View Article and Find Full Text PDFArticle Synopsis
- - Anticancer systemic therapy includes a diverse range of drugs, with new agents that have unique mechanisms of action challenging traditional classifications like chemotherapy and monoclonal antibodies.
- - The proposed classification system categorizes these drugs based on two factors: where they act (tumor cells, blood vessels, immune system, endocrine system) and how they work (the specific molecular target).
- - This approach aims to better understand and organize the growing complexity of cancer treatments to improve their effectiveness and application.
Salivary gland squamous cell carcinomas (SG-SCCs) constitute a rare type of head and neck cancer which is linked to poor prognosis. Due to their low frequency, the molecular mechanisms responsible for their aggressiveness are poorly understood. In this work we studied the role of the phosphatase DUSP1, a negative regulator of MAPK activity, in controlling SG-SCC progression.
View Article and Find Full Text PDFThyroid cancer is the most frequent endocrine tumor. In locally advanced or metastatic disease there are only two types of treatment available: radioactive iodine (RAI) while the disease is RAI-sensitive and multikinase inhibitors, lenvatinib and sorafenib, when the disease becomes RAI-refractory. The objective of this publication is to review the current knowledge on the use of targeted therapy and the specific practical considerations concerning lenvatinib in the treatment of patients with differentiated thyroid cancer under special circumstances.
View Article and Find Full Text PDFLong-term complete remission of metastatic adrenocortical carcinoma.
Horm Mol Biol Clin Investig
March 2023
Objectives: To report a rare case of a metastatic adrenocortical carcinoma (ACC) that achieve a complete and a long-term remission.
Case Presentation: AAC is a rare and aggressive tumor, with a high risk of recurrence and that present metastases in 21% of cases at diagnosis. Treatment of advanced ACC is challenging, mitotane is the only available adrenolytic treatment, with modest and unpredictable responses.