Publications by authors named "B Castelli"

Introduction: In childhood, growth hormone (GH) deficiency (GHD) diagnosis is based on auxological assessment and biochemical provocative tests, whose reliability remains disputed. Recently, several papers have been published on standardising the duration of some tests. The aim of our study was to analyse the possible length reduction of the L-DOPA provocative test.

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Article Synopsis
  • Dabrafenib plus trametinib shows strong effectiveness and manageable side effects for patients with -mutant glioma.
  • There is a notable case of a patient with recurrent anaplastic pleomorphic xanthoastrocytoma who had a complete and lasting response to this treatment.
  • Continued development of targeted therapies and treatment strategies is expected to enhance personalized care for high-grade glioma patients, ultimately improving their outcomes.
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Background: Craniopharyngioma (CP), although slow growing and histologically benign, has high morbidity, mostly related to hypothalamus-pituitary dysfunction and electrolyte imbalance. Increased risk of vascular complications has been described. However, data are still poor, especially in the paediatric population.

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Low grade gliomas (LGGs) of pineal region are usually difficult to remove and they frequently relapse or progress after front line chemotherapy. Bevacizumab-Irinotecan (BEVIRI) combination has been successfully attempted in children with recurrent LGGs, in most cases not previously irradiated. The efficacy of bevacizumab has also been described in radiation necrosis.

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