Multimodality Radiologic and Pathologic Findings in Large B-cell Lymphoma With Hepatic Presentation in an Unusually Young Male.

Diffuse large B-cell lymphoma (DLBCL) is the most prevalent type of non-Hodgkin lymphoma (NHL), and typically presents in patients who are at least 60 years old with gastrointestinal (GI) tract involvement. We report a case of a young patient with DLBCL. A 27-year-old African American male presented to the emergency room with complaints of abdominal distention.

Unilateral Diaphragmatic Paralysis: A Case Report of an Often Overlooked Diagnosis.

Unilateral diaphragmatic paralysis, resulting from nerve or muscle injuries, is an uncommon phenomenon often missed due to its asymptomatic nature. This condition can lead to decreased pulmonary function, particularly in patients with underlying comorbidities or cardiopulmonary issues. Identification and understanding of the underlying cause of the paralysis are essential for effective management and improved patient outcomes.

Gestational cholestyramine treatment protects adult offspring of ApoE-deficient mice against maternal-hypercholesterolemia-induced atherosclerosis.

Aim: Perinatal hypercholesterolemia exacerbates the development of atherosclerotic plaques in adult offspring. Here, we aimed to study the effect of maternal treatment with cholestyramine, a lipid-lowering drug, on atherosclerosis development in adult offspring of hypercholesterolemic ApoE-deficient (ApoE) mice.

Methods: ApoE mice were treated with 3% cholestyramine (CTY) during gestation (G).

Rigorous science demands support of transgender scientists.

To build a just, equitable, and diverse academy, scientists and institutions must address systemic barriers that sex and gender minorities face. This Commentary summarizes (1) critical context informing the contemporary oppression of transgender people, (2) how this shapes extant research on sex and gender, and (3) actions to build an inclusive and rigorous academy for all.

Dual Effect of Secondary Solutes on Binding Equilibria: Contributions from Solute-Reactant Interactions and Solute-Water Interactions.

This study examines the role of water in binding equilibria with a special focus on secondary solutes (cosolutes) that influence the equilibrium but are not constituents of the final product. Using a thermodynamic framework that includes an explicit term for the release of water molecules upon binding, this investigation reveals how solutes may alter equilibria by changing the activity of the reactants, reflected in Δ°, and by changing the chemical potential of the solvent, reflected in Δ. The framework is applied to four experimental binding systems that differ in the degree of electrostatic contributions.