Publications by authors named "B Cariou"
NMR is a central tool in the field of metabolomics, thanks to its ability to provide valuable structural and quantitative information with high precision. Most NMR-based metabolomics studies rely on 1D H detection, which is heavily limited by strong peak overlap. C NMR benefits from a wider spectral dispersion and narrower signal line width but is barely used in metabolomics due to its low sensitivity.
View Article and Find Full Text PDFObjective: To assess the accuracy of "diabetes overtreatment" proxy definitions in predicting hypoglycemia in older adults with type 2 diabetes (T2D).
Research Design And Methods: Inclusion of patients from HYPOAGE cohort with insulin-treated T2D, aged ≥75 years, and using a continuous glycemic monitoring (CGM) device for 28 days. "Diabetes overtreatment" was defined as HbA1c <7.
Introduction: Inclisiran, an siRNA targeting hepatic PCSK9 mRNA, administered twice-yearly (after initial and 3-month doses), substantially and sustainably reduced LDL-cholesterol (LDL-C) in Phase III trials. Whether lowering LDL-C with inclisiran translates into a reduced risk of major adverse cardiovascular events (MACE) is not yet established. In-silico trials applying a disease computational model to virtual patients receiving new treatments allow to emulate large scale long-term clinical trials.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on dysbetalipoproteinemia (DBL), a lipid disorder linked to cardiovascular disease risk, especially in individuals with the ε2ε2 genotype, and evaluates the effectiveness of nine different screening algorithms, including a new one developed by the researchers.
- - Patients were classified into three groups based on their genetic background and the diagnostic performance of the algorithms was assessed against a gold standard of specific triglyceride levels and genotypes.
- - The findings indicate that the "Hospices Civils de Lyon (HCL) algorithm" demonstrated superior diagnostic ability for detecting DBL in both ε2ε2 and rare variant carriers compared to other algorithms, highlighting the need for further investigation into the accuracy of these screening methods.