Publications by authors named "B Calero Ayala"
Article Synopsis
- Left bundle branch pacing (LBBP) is a potential alternative to cardiac resynchronization therapy (CRT) but is not suitable for all heart failure patients.
- A study analyzed 187 CRT candidates, finding a success rate of 81.2% for LBBP implantation, with failed cases primarily due to poor QRS morphology and technical issues.
- Key predictors for unsuccessful implantation included left ventricular end-diastolic diameter (LVEDD) and non-left bundle branch block (non-LBBB) morphology, with non-LBBB significantly increasing the risk of failure.
Article Synopsis
- The REGAIN trial found that spinal and general anesthesia provide similar outcomes regarding ambulation and survival after hip fracture surgery.
- In a secondary analysis, researchers compared pain levels, analgesic use, and patient satisfaction between the two anesthesia types.
- Results indicated that spinal anesthesia led to more severe pain in the first 24 hours post-surgery and higher prescription analgesic use at 60 days, while patient satisfaction remained comparable across both groups.
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
N Engl J Med
January 2016
Background: Papillary renal-cell carcinoma, which accounts for 15 to 20% of renal-cell carcinomas, is a heterogeneous disease that consists of various types of renal cancer, including tumors with indolent, multifocal presentation and solitary tumors with an aggressive, highly lethal phenotype. Little is known about the genetic basis of sporadic papillary renal-cell carcinoma, and no effective forms of therapy for advanced disease exist.
Methods: We performed comprehensive molecular characterization of 161 primary papillary renal-cell carcinomas, using whole-exome sequencing, copy-number analysis, messenger RNA and microRNA sequencing, DNA-methylation analysis, and proteomic analysis.
Background: Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted on the basis of histologic class. Some are indolent; others quickly progress to glioblastoma. The uncertainty is compounded by interobserver variability in histologic diagnosis.
View Article and Find Full Text PDFObjective: Paraoxonase 1 (PON1) plays an important role in reducing the risk of coronary heart disease (CHD). Smoking is known to reduce PON1 activity. We aimed to investigate the effects of interactions between PON1 variants and smoking on CHD in the Singaporean Chinese population.
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