Publications by authors named "B C Whitfield"

The transfer of large-area, continuous, chemical vapor deposition (CVD)-grown graphene without introducing defects remains a challenge for fabricating graphene-based electronics. Polymer thin films are commonly used as supports for transferring graphene, but they typically require thermal annealing before transfer. However, little work has been done to thoroughly investigate how thermal annealing affects the polymer/graphene thin film when directly annealed on the growth substrate.

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Article Synopsis
  • Inactivation of the ATRX gene is a key feature of malignant gliomas, leading to G-quadruplex (G4) DNA structures that cause replication stress and genomic instability.
  • The study tested a drug, CX-5461, on glioma stem cells and mouse models, both alone and with radiation, showing it was particularly effective against ATRX-deficient tumors.
  • The results revealed that CX-5461 increased DNA damage and cell death specifically in ATRX-deficient models, reduced tumor growth, and improved survival in mice, highlighting its potential as a new treatment approach for this type of cancer.
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To assess the associations between the executive order that Texas governor Greg Abbott issued on March 22, 2020, postponing procedures deemed not immediately medically necessary, and patients' access to abortion care in Texas. We used 17 515 individual-level patient records from 13 Texas abortion facilities for matched periods in 2019 and 2020 to examine differences in return rates for abortion after completion of a state-mandated ultrasound and median wait times between ultrasound and abortion visits for those who returned. Patients were less likely to return for an abortion if they had an ultrasound while the executive order was under effect (82.

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Unlabelled: Lack of robust activation of Stimulator of Interferon Genes (STING) pathway and subsequent induction of type I IFN responses is considered a barrier to antitumor immunity in acute myeloid leukemia (AML). Using common human AML cell lines as in vitro tools to evaluate the efficacy of novel STING agonists, we found most AML lines to be poor producers of IFNs upon exposure to extremely potent agonists, suggesting cell-intrinsic suppression of STING signaling may occur. We observed unexpected patterns of response that did not correlate with levels of STING pathway components or of known enzymes associated with resistance.

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